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Researchers have identified 10 new cancer risk genes

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10 new cancer risk genes

ISLAMABAD: Using publicly available data, researchers have identified 10 new genes that are predisposed to cancer among others, an advance that would contribute to improving cancer diagnoses and prevention in the future.

There are many genetic causes of cancer. While some mutations are inherited from parents, others are acquired all throughout life due to external factors or due to mistakes in copying DNA. In the study, published in Nature Communications, a team of researchers developed a new statistical method named ALFRED and identified 13 candidate cancer predisposition genes, of which 10 are new from tumour sequencing data.

“We applied our method to the genome sequences of more than 10,000 cancer patients with 30 different tumour types and identified known and new possible cancer predisposition genes that have the potential to contribute substantially to cancer risk,” said principal investigator Ben Lehner, ICREA – Catalan Institution for Research and Advanced Studies in Spain. “Our computational method uses an old idea that cancer genes often require ‘two hits’ before they cause cancer.

We developed a method that allows us to systematically identify these genes from existing cancer genome datasets,” said Solip Park, from the Centre for Genomic Regulation (CRG) – a Barcelona-based research facility. For the study, the team combined data from many different projects and by applying a new computational method, were able to identify important cancer genes that were not identified by the original studies.

Relevant pieces published earlier: 

i) According to a new report on cancer treatments that attack tumors based on their individual genetic traits – not their location in the body – far outperform traditional methods, extending survival for twice as many patients. The precision medicine field of targeted therapy involves testing tumors for clues about their genetic mutations, and matching patients with new drugs designed to block cancer’s growth on a molecular level. Researchers in Texas began studying the impact of these therapies in 2007, after seeing the success of Gleevec (imatinib) – a breakthrough drug approved by US regulators in 2001 that showed huge success against chronic myeloid leukemia. The results of the first and largest precision medicine trial to look at survival across a host of cancer types and many different targeted therapies were released at the American Society of Clinical Oncology meeting in Chicago, the world’s largest annual cancer meeting. The study, called IMPACT, enrolled 3,743 patients at Texas MD Anderson Cancer Center from 2007 to 2013. All the patients had advanced cancers, or “end-stage disease,” involving cancers of the gastrointestinal tract, breast, or lung. Melanoma and cancer of the female reproductive tract were also included, along with more rare types of cancer. Those enrolled had typically tried at least four – and sometimes up to 16 – other treatments that failed to halt the growth of their cancer. Patients who received molecularly targeted therapies either got an investigational drug then being tested in a clinical trial or an FDA-approved targeted therapy commercially approved for another indication.

ii)  Consumption of broccoli has long been linked to innumerable health boons. Considering this, savants have further claimed that it could fend off Type 2 Diabetes (T2D). As per their findings, ingesting its extracts could potentially assist people suffering from T2D to control over their blood sugar levels. This magical veggie is stuffed with vitamins, fiber, and disease-combating phytochemicals, which may help overturn the disease symptoms. So as to prove this, scholars have given concentrated broccoli sprout extracts to some 97 participants with T2D for around 12 weeks. Their findings demonstrated that those, who had dysregulated disease, have been reported with considerably reduced fasting blood glucose levels and glycated hemoglobin (HbA1c) when compared to others. Apart from this, a couple of previous researches have shown that broccoli has the potential to decrease cholesterol levels. Also, its daily consumption might make your bones stronger, detoxify your body and maintain the digestive system and vision. Not to mention that broccoli could oust the expansion of lethal cancer cells. According to the statistics, around 450 million folks come up in T2D across the globe. Regrettably, more than 15 percent of those patients cannot receive the first-line cure metformin due to kidney damage hazards. Journal Science Translational Medicine has published their ramifications. (23rd of June, 201

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Caretaker CM inaugurates Institute of Cardiology Wazirabad

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LAHORE: Caretaker Chief Minister Punjab Dr. Hasan Askari today inaugurated the Wazirabad Institute of Cardiology.
After inauguration, he visited the institute and inspected its different sections. He also met with patients and inquired about their health. The institute will facilitate patients from six districts of the division with the latest medical treatments.
The Wazirabad Institute of Cardiology is equipped with the latest facilities, including heart surgeries, CCU, cardiac emergency, angiography, angioplasty, eco-cardiograph, radiology and technical laboratories.
This project whose foundation stone was laid in 2006 and construction started in 2007, however, it was made operational fully after 12 years by the interim government.
The institute capacity of 200 beds and initially arrangement of 100 beds are available. It will provide around 50 lac patients with the latest medical facilities. With the establishment of the Wazirabad Institute of Cardiology, patients would not be needed to refer to Lahore or other big cities. The OPD was established in this institute in 2014 and in 2016 a coronary angiography facility was made available to the public.
Now in 2018, it offers 24 hours emergency and the latest facilities of CCU and cardiac surgery. Many senior registrars of cardiology, senior registrar cardiac surgery, 33 medical officers and 58 nurses are performing their duties in the institute.
While addressing on this occasion, the caretaker CM said that in-time completion of such projects was the need of the hour as it would provide people of that area with quality medical facilities.
He said that serving humanity was the responsibility of everyone along with the government and the role of doctors and nurses in this noble cause was undeniable.
He said that the facility inaugurated today would flourish further in future and will assist the
community. Patients not only from Wazirabad but from Gujranwala division and other neighboring areas will also benefit from this hospital whose credit went to the collective teamwork, he added.
Hassan Askari said that even though it took 12 long years to complete this project but:” We hope that other needful facilities will be provided within time”.
He congratulated Caretaker Health Minister Jawad Khan and his team who worked hard day and night to complete this project and now it was attending 1,500 patients on average on a daily basis.
Hassan Askari said:”Some of the complaints rigging out were related to the federal and other departments and addressing them was not in our control nevertheless we are trying to address the complaints which fall in our jurisdiction”.
A strategy had been devised in this regard, likewise, Caretaker Interior Minister Shaukat Javed took instant action against these complaints while implementation of the code of conduct issued by the Election Commission was also ensured, he said. The interim Punjab government was assisting in electoral process under the framework of the Election Commission and political parties were also taken on board, He said and added proper security was being provided to political gatherings.
Hassan Askari added that cooperation on every level was mandatory for transparent elections and:” It is our utmost priority to provide a peaceful, free and independent environment for it”. He said:” The independent election can take place only if we cooperate with each other,” Answering another question, Dr. Hassan Askari said that prisoners in jail were provided with facilities according to their status and categories.
Later, Dr. Hassan Askari inaugurated afforestation campaign by planting a plant in the garden of Institute of Cardiology. Provincial Caretaker Ministers Zai Haider Rizvi, Dr. Jawad Sajid Khan, Sectary Specialized Health Care, Medical Education and other concerned authorities were also present.

 

 

 

 

 

 

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High risk of ‘losing control’ of AIDS epidemic: experts

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AMSTERDAM: The AIDS epidemic risks resurging and spiraling out of control unless billions of extra dollars are pumped into prevention and treatment, experts warned today on the eve of a major world conference.
An alarming rate of new infections, coupled with an exploding population of young people in hard-hit countries, meant the world could be steering for “a crisis of epic proportions,” said Mark Dybul, an American AIDS researcher and diplomat.
“Bad things will happen if we don’t have more money,” he told a special event organised a day before some 15,000 delegates attend the opening of the International AIDS Conference in Amsterdam.
The world was “probably at the highest risk ever of losing control of this epidemic because of demographics and because of countries not paying attention the way they once did, or never did in some cases,” warned Dybul.
UNAIDS last week reported a record number of HIV-positive people using life-saving antiretroviral therapy (ARV), and lower rates of deaths and new infections — though not low enough according to campaigners.
And even this progress risks being overturned.
Speakers warned that donor and domestic funding has dropped significantly, and would likely continue declining.
Under Donald Trump, the US administration has proposed massive spending cuts, though these have failed to pass through Congress so far.
The US is by far the biggest funder of the global AIDS response. According to UNAIDS executive director Michel Sidibe, there was a funding gap of almost $7 billion (about six billion euros).
“If we don’t pay now we will pay more and more later,” he told the meeting. Experts lamented that the successful rollout of life-saving, virus-suppressing drugs may have diverted necessary attention, and cash, away from the need to curb new HIV infections.
ARVs are also increasingly being used, mainly in rich countries, to prevent contracting the virus from sex. To meet the UN goal of ending AIDS as a public health threat by 2030, infections must be limited to 500,000 per year globally in just two years’ time.
Last year’s 1.8 million new infections showed that “unless we did something completely drastic, we will not get anywhere near” the goal, said Nduku Kilonzo of Kenya’s National AIDS Control Council.

 

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Amputations in diabetic patients can be prevented by care

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HYDERABAD: Vice Chancellor Liaquat University of Medical and Health Sciences (LUMHS) Prof. Bikha Ram Devrajani has advised diabetic patients to adopt special care as approximately 1 in 5 cases of infected diabetic foot ulcers end up at amputation.
Addressing a workshop on “Diabetic Foot” here today he informed that diabetes mellitus is a chronic disease caused by the body’s inability to produce and use insulin. and such a deficiency results in increased concentrations of glucose in the blood, which in turn damage many of the body’s systems.
The workshop was arranged by Sindh Institute of Endocrinology & Diabetes LUMHS Jamshoro in collaboration with Baqai Institute of Endocrinology & Diabetology at Liaquat University Hospital Jamshoro.
Prof. Devrajani informed that Diabetic complications of foot-one of the most common and visible impacts of the disease- were caused by changes in blood vessels and nerves and that can lead to ulceration and subsequent limb amputation. Diabetic foot ulcers can occur in up to 25 percent of patients with diabetes during their lifetimes and more than half of those ulcers will become infected, he informed.
He said that the daily life of diabetic patients is disrupted by the need of monitoring blood glucose levels, taking medicines and balancing the effect of activity and food. Professor Bekha Ram further informed that amputations due to diabetes cause unnecessary loss of life and disability. In high-income countries, treatment of diabetic foot complication accounts for 15-25 percent of total health care resources for diabetes, he added.
Professor Bekha Ram informed that the leg and foot amputations in people with diabetes can be prevented using low cost, low technology solutions and simple behaviors should be encouraged such as regular foot examination and examining the inside of shoes before putting them on, not walking barefoot, wearing comfortable shoes, keeping feet clean and regular care of skin and nails. He added that people who suffer from diabetes must take special care of their feet, as they are at a higher risk of infection and necrosis that can lead to amputation.

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